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Production of pharmaceutical hard capsule shell from corn starch

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This thesis is not published due to patent processrnrnThere is a growing interest in the consumption of non-animal capsule. Most of non- animal capsule is produced from Hydroxypropyl Methylcellulose (HPMC). However, the material is relatively more expensive. The aim of this research is to produce hard capsule shell from other material which is readily available in Indonesia. The availability of corn in Indonesia in large amount and in a reasonable price made it an interesting source for capsule shell material. The hard capsules obtained with a conventional dipping molding process. The materials used in this research are corn starch, glycerol, carrageenan and demineralized water. Hard capsules shell can be produced with composition of corn starch 20%, glycerol 5.3%, carrageenan 0.5% andrndemineralized water 74.2%. The capsules have opaque appearance and are elastic but they are not as strong as gelatin capsules. The performance of corn starch capsules was compared to gelatin capsules. The disintegration time of corn starch capsule is 576+72 seconds; the thickness is 0.38+0.05 mm and the moisture content is 10.96+1.17%. The overall performances are within acceptable limit except for thickness.

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Availability

B00611

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Available

Detail Information

Series Title

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Call Number

611

Publisher

: Swiss German University., 2009

Collation

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Language

English

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Classification

NONE

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Edition

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Subject(s)

PE

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