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Development of Particle Size Determination Model in High Shear Mixing Wet Granulation

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Rapid growth rate in high shear mixing wet granulation demands better understanding of its growth kinetics in order to monitor and modify the process. This research aims to report the significance of several process variables in correlation with particle growth. Growth kinetic model was expected to be found and provide implications to granulation technology. Initial particle size, impeller speed and chopper speed was set at two levels of treatment in a binary mixture of lactose and water. the mean size of granules obtained was analyzed through laser diffraction and grid counting method. It was observed that smaller initial size produced larger granules (42.438 ¬¨¬µm into 277.514 ¬¨¬µm‚Äö?Ñ?¨5.5038 mm vs. 83.712 ¬¨¬µm into 152.513 ¬¨¬µm‚Äö?Ñ?¨4.5187 mm). Impeller speed showed different trends in correlation with energy threshold for growth (e.g. 220 rpm into 382.487 ¬¨¬µm and 110 rpm into 446.035 ¬¨¬µm vs. 220 rpm into 348.222 ¬¨¬µm and 110 rpm into 152.513 ¬¨¬µm). Higher chopper speed was effective in reducing size (e.g. 1500 rpm into 4.4861 mm vs. 750 rpm into 5.4225 mm). Particle growth was steady for granules below 2 mm, while granules above 2 mm showed relatively unsteady growth. Granule growth was extremely fast and granulation is not governed by chemical properties.

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Availability

B01737

(Rack Thesis)

Available

Detail Information

Series Title

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Call Number

1737

Publisher

: Swiss German University., 2014

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Carrier Type

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Edition

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Subject(s)

PE
Granulation
High shear
Growth
Binary mixture
End point

Specific Detail Info

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