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Development of eye drops from natural extract of butterfly pea petal extract as the active pharmaceutical ingredient

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Empirically the blue water extract from butterfly pea petal has been used as a traditional eye drops to relieve eye irritations such as eye redness and dry eyes. The purpose of this research was to develop the butterfly pea petal extract as the active ingredients for eye drops product. The sterility, stability, and compatibility of the extract as the active ingredients for eye drops product were examined. The sterility of the extract was achieved by doing two techniques; autoclaving the extract and by pasteurization. The stability of the extract was examined during 14 days storage period. The compatibility was examined by adding the extract to eye drops excipients, such as commercial eye drops solution, NaCl + Na2EDTA solution, and NaCl solution. Autoclaving at 121oC for 15 minutes and pasteurization at 80-90oC for 30 minutes were effective to sterilize the extract and were able to preserve the bioactive compound that act as the antimicrobial. The butterfly pea petal was compatible with NaCl solution. The MIC for Escherichia coli and Staphylococcus aureus were 75┬╡l/ml and 130┬╡l/ml, respectively.

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Availability

B01255

(wh)

Available

Detail Information

Series Title

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Call Number

1255

Publisher

: Swiss German University., 2012

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

PE

Specific Detail Info

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Statement of Responsibility

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