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Microenvironment approach for low humidity production process using compressed dry air

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The manufacture of pharmaceutical products may require room facilities where a low level humidity is desired. To attain 15-25% relative humidity, the use of HVAC and desiccant dehumidifiers are employed widely in pharmaceutical industries. However many consideration on effect of low relative humidity to health and economic cost are still a challenge to resolve. An alternative to localize dehumidification at its critical points was attempted using a microenvironment approach. Utilizing compressed dry air with rH 0.20% , an acrylic model box with volume of 0.064 m3 was devised to simulate profile dilution of relative humidity over time. Model box also mapped to ensure impact on process quality. Homogeneity of humidity is found not be affected by inlet port location. With an inlet airflow of 80 L/min, 15% relative humidity is obtainable in 71 seconds. Upon the removal of air input, the relative humidity within the box increased to 25% in 571 seconds. A prospective application on production process may be applied to manufacturing of products that are moisture sensitive and where a closed processing can be employed.

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Availability

B01257

(wh)

Available

Detail Information

Series Title

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Call Number

1257

Publisher

: Swiss German University., 2012

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

PE

Specific Detail Info

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Statement of Responsibility

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