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The creation of bromelanin lozenges from pineapple (ananas comosus)

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Pineapple has a proteolytic enzyme called bromelain. Recent discovery, bromelain has the potential to treat HIV/AIDS patients. The problem is that pineapple has very short shelf life and very easy to spoil. Bromelain in table form has relatively longer shelf life and can be consume anytime and anywhere. In this research, the bromelain tablet was produced with wet granulation, drying process and tablet compression. Another problem with drying is bromelain is heat sensitive and can lose activity so excipients such as binder, filler, disintegrant, lubricant and preservative was added at the granulation process before the drying process. The addition of excipients can protect the bromelain but at the same time, it reduce the amount of active pharmaceutical ingredient by diluting the bromelain with excepients by several times. The best possible formulation needed to be discovered in order to make a good tablet and at the same time it protect the bromelain enzyme activity in the tabler form.

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Availability

B01259

(wh)

Available

Detail Information

Series Title

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Call Number

1259

Publisher

: Swiss German University., 2012

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

PE

Specific Detail Info

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Statement of Responsibility

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