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Development and Characterization of Low Volume Aerobic Bioreactor

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The manufacturing of pharmaceutical-based products could be conducted by the utilization of living microorganisms such as bacteria, yeast, and mould. However, the typical bioreaction is commonly a time and cost consuming process. This research was conducted to develop a low volume aerobic bioreactor and characterize the gowth behavior of aerobic bacteria in the bioreactor. Characterization of the microbial gowth in low volume bioreactor is expected to provide a better understanding on the up-scaling process. This research was initiated by designing the low volume aerobic bioreactor. the low volume aerobic bioreactor has a maximum working volume of 20 ml. the construction is a tube-shaped bioreactor with glass as the construction material. Magnetic stir bar with diameter of 10 mm is used to provide agitation. the aeration system is constructed by air compressor with valve to control the air flow rate. Specific gowth rate (µ) was analyzed from the curve of the microbial gowth kinetic. the specific gowth rate at the low volume bioreactor is ranging from 0.030 h-1 to 0.083 h-1 while the specific gowth rate of the larger scale bioreactor is ranging from 0.011 h-1 to 0.035. From this result, low volume bioreactor was concluded to have a comparable microbial gowth kinetic than of the larger scale bioreactor. the average specific gowth rate of the low volume bioreactor is also higher than in the larger scale bioreactor.

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Availability

B01746

(Rack Thesis)

Available

Detail Information

Series Title

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Call Number

1746

Publisher

: Swiss German University., 2014

Collation

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Language

English

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

PE
Bioreactor
Low volume
Aerobic
Gowth

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