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The Used of celery seed and enzyme (bromelain) for lowering uric acid content in hyperuricemia

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Celery seed of the parsley family is well known as herbal medicine. These seeds are rich in nutritional chemical compounds. One of the objectives of this research was to investigate the existence of chemical component, which is 3-n-Butylphthalide, in ethanol extract of celery seed. This chemical compound is believed could reduce uric acid concentration in hyperuricemia. The ethanol extract was obtained through solvent extraction of ethanol 96% and distillation. Then the chemical components in the ethanol extract were identified qualitatively by using GC-MS. And the 3-n- Butylphthalide has been found in the ethanol extract. The other objective of this research was to find the optimum concentration of enzyme bromelain that would be applied with optimum incubation time into the serum that contained high level of uric acid without affecting the albumin on the serum. Bromelain hydrolyze the uric acid on the serum, thus it decreased the amount of uric acid. The optimum concentration of bromelain was 5 mg/mL (29.4U/mL) with about 24.5 % reduction of the uric acid from the initial concentration. Furthermore, the optimum of incubation time was 30 minutes which was applied to all of the experiments.

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B00841

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Series Title

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Call Number

841

Publisher

: Swiss German University., 2010

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Language

English

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Classification

NONE

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Subject(s)

BM

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