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Preliminary study of antivirus for Hepatitis C Virus (HCV) using protease enzyme (bromelain)

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In a previous in-vitro research, Bromelain, a protease found in the fruit and stem of pineapples, has been shown to deactivate the Human Immunodeficiency Virus (HIV) and produced negative results on the rapid HIV-strip test. It is hypothesized that Bromelain could act as a possible antivirus to the Hepatitis Virus C (HCV) by destroying the envelope glycoproteins E1 and E2 in the outer layer of HCV that helps the virus reproduce. In this research, the effect of Bromelain on HCV is investigated using the MONOTM Anti-HCV Test. The research was done by incubating HCV-positive serums with Bromelain solution of various concentrations at 37oC for up to 6 hours. The result of the MONOTM Anti-HCV Test showed negative results after 1 hour of incubation with Bromelain solution with a concentration of 20 mg/mL and a specific activity of 4.395 U/mg. The Bromelain treatment causes serum Albumin levels to decrease by 25-30% and Total Protein and Globulin content to increase.

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Availability

B01113

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Detail Information

Series Title

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Call Number

1113

Publisher

: Swiss German University., 2012

Collation

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Language

English

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Classification

NONE

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Edition

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Subject(s)

BM

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