Acute toxicity Study of Butterfly Pea Leaf Extracts on Experimental Mice
The extracts of butterfly pea leaves have been suggested to be an effective cure for diabetes. This study has the objective to test the acute oral toxicity of the extracts. Powder form of the extracts was initially prepared through freeze-drying process and was orally administered in high concentration to thirty male experimental mice (Mus musculus). the test method used in the study was based on OECD guidelines no. 423. Six dose concentrations of 2500mg/kg bw, 50000mg/kg bw, 10000mg/kg bw, 20000mg/kg bw, 40000mg/kg bw and 80000mg/kg bw were evaluated. Signs of toxicity and mortality rate were recorded and evaluated during a 4-hour critical observation and 7 days daily observation. the 3 first lower doses have 0% mortality rate while the highest dose have 100% mortality rate. Using probit analysis, the LD50 value of the extracts was revealed to be 19380.692mg/kg bw and classified as practically non-toxic.
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