Evaluation of antioxidant, alpha-glucosidase inhibitory and antimicrobial activities of extract of peel, seed and fruit flesh and endocarp of pometia pinnata

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Evaluation of antioxidant, alpha-glucosidase inhibitory and antimicrobial activities of extract of peel, seed and fruit flesh and endocarp of pometia pinnata

Adhitama, Imelda - Personal Name; Santoso, Filiana - Personal Name; Pandiangan, Febbyandi I - Personal Name;

The research investigated the potential activities of the peel, seed, fruit flesh and endocarp of Pometia pinnata as natural sources for antioxidant, alpha-glucosidase inhibitor and antimicrobial agents. The total phenolic and flavonoid contents of the extracts were also determined and correlated to the activities. Three solvents with different polarity (hexane, ethyl acetate and methanol) were applied in the gradient extraction of the fruit. The endocarp methanolic extract exhibited the strongest antioxidant activity against DPPH radical compounds (IC50 0.27 ?g/ml), even significantly stronger than commercial antioxidant, L-Ascorbic acid (IC50 8.10 ?g/ml). The extract was also found to have the highest total phenolic and flavonoid contents. In addition, it revealed the highest alpha-glucosidase inhibitory activity against sucrose and maltose hydrolysis by rat intestinal enzyme, though it was significantly lower than the commercial inhibitor acarbose. Furthermore, the flesh methanolic extract also showed similarly high activity in maltase inhibition. All crude extracts showed bacteriostatic capacity, but the MIC from broth macrodilution against Staphylococcus aureus and Escherichia coli were only detected in the endocarp methanolic extract with both MIC 500 ?g/ml. In conclusion, methanol was found to capable of extracting bioactive compounds contributing as antioxidant, AGI and antimicrobial agents. The endocarp methanolic extracts particularly showed the highest potency in all activities, which was discovered in this study for the first time.

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B03108 (Rack Thesis) Available

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Series Title: -
Call Number: 3108
Publisher: : Swiss German University., 2019
Collation: -
Language: English
ISBN/ISSN: -
Classification: NONE
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): FT
Antioxidant
Antimicrobial
Alpha-glucosidase inhibitor
Phenolic
Flavonoid
Specific Detail Info: -
Statement of Responsibility: -

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