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Evaluation of antifungal activity of lemongrass extract and its key components against mallasezia sp.

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In this research, the antifungal performance of lemongrass essential oils extracted from leaves and stems were tested against Malassezia furfur, the fungi responsible for pityriasis capitis (dandruff), pityriasis versicolor, and seborrheic dermatitis. The antifungal activities of its key constituents namely citral, citronellol, and citronellal were also tested. Moreover, the synergistic effect between each constituent and essential oils were also assessed. Disc diffusion assay was applied to test the inhibitory effect. Both lemongrass essential oils from the leaves and stems exhibited better antifungal activities against M. furfur compared to synthetic antifungal ketoconazole 2%. The inhibitory effects increased correspond to the volume of tested compounds applied on disc. Among the key constituents, citral exhibited the most active antifungal performances followed by citronellol and citronellal respectively. The results in this study revealed that the combinations of lemongrass oils, citral and citronellal exhibited a synergistic effect in inhibiting the human pathogenic fungus, Malassezia furfur.rnKeywords: lemongrass essential oil, antifungal, Malassezia furfur, citral, citronellol, citronellal, zone of inhibition, synergistic.

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B00618

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Detail Information

Series Title

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Call Number

618

Publisher

: Swiss German University., 2009

Collation

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Language

English

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Classification

NONE

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Edition

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Subject(s)

PE

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