Isolation and Cytotoxic Assay of Alkaloid Compounds From Soursop Leaves (ANNonA Muricata L.)

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Isolation and Cytotoxic Assay of Alkaloid Compounds From Soursop Leaves (ANNonA Muricata L.)

Soegiharto, Jesslin Rani - Personal Name; Pandjaitan, Maruli - Personal Name; Marpaung, Abdullah Muzi - Personal Name;

NOTES: CD not availablernThe research investigated the amount of total alkaloid content that can be obtained from various maturity of soursop leaves and extraction temperature. the maturity of soursop leaves were divided into 2 clusters, namely young soursop leaves (4th-6th leaves order) and old soursop leaves (7th-10th leaves order), while the extraction temperature were varied into 50oC, 60oC, 70oC, and 80oC. Through several extraction process, the total alkaloid content extracted from young soursop leaves yielded more total alkaloid content compare to the old soursop leaves. the total alkaloid content acquired from extraction of 23.33 grams powdered young soursop leaves at 50oC was 0.301%, which is equivalent to 0.07 gram. GC-MS analysis detected the presence of alkaloid compounds, namely 4H-Dibenzo[de,g]quinoline-1,9-diol,5,6,6a,7-tetrahydro-2,10-dimethoxy-6-methyl-,(S)- or commonly named isoboldine (C19H21NO4) with molecular weight of 327g/mol. in Brine Shrimp Lethality Test (BSLT) test, the LC50 value of the sample was 268.55 ppm (

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B01761 (Rack Thesis) Available

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Series Title: -
Call Number: 1761
Publisher: : Swiss German University., 2014
Collation: -
Language: English
ISBN/ISSN: -
Classification: NONE
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): FT
Annona muricata
Alkaloids
Cytotoxic assay
Lethal concentration
Inhibition concentration
Specific Detail Info: -
Statement of Responsibility: -

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